Which enzyme converts androgens to estrogens and where is it found?
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Asked by: Paul Brunhaver
The CYP19A1 gene provides instructions for making an enzyme called aromatase. This enzyme converts a class of hormones called androgens, which are involved in male sexual development, to different forms of the female sex hormone estrogen.
Where is aromatase enzyme located?
The enzyme aromatase can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.
Where are androgens and estrogens produced?
Estrogens are produced by the body in greater amounts in females. They are necessary for normal sexual development of the female and for regulation of the menstrual cycle during the childbearing years. Androgens are produced by the body in greater amounts in males.
What hormone converts androgens into estrogen in the adipose tissue?
Adipose tissue is involved in the metabolism of androgen to estrogen known to be converted by ARO found in fat tissue.
Where does androgen aromatization occur?
2 Aromatase
Aromatization of testosterone to estradiol occurs in several tissues of the adult male, including adipose, testis (Sertoli cells and Leydig cells), brain, bone, breast, liver, and blood vessels.
Where is estrogen produced?
ovaries
The woman’s ovaries make most estrogen hormones, although the adrenal glands and fat cells also make small amounts of the hormones.
Where are androgens formed quizlet?
Androgens are produced in the adrenal glands. Testosterone is produced in the testes.
What enzyme converts testosterone to estradiol?
aromatase
Abstract. Estrogens are generated mainly by the action of aromatase, which converts testosterone to estradiol and androstenedione to estrone.
Which of the following enzymes is needed to convert testosterone to estrogen?
Aromatase is an enzyme that catalyzes the rate-limiting step of testosterone and androstenedione conversion into estradiol and estrone.
Which enzyme is responsible for creating estrogen in the body?
The enzyme aromatase is found in a number of human tissues and cells, including ovarian granulosa cells, the placental syncytiotrophoblast, adipose and skin fibroblasts, bone, and the brain, and it locally catalyzes the conversion of C(19) steroids to estrogens.
