What is roller compaction?

Asked by: Jami Garcia

Roller Compaction A compaction unit, where the powder is compacted between two counter rotating rolls by applying a force, to form ribbons or flakes. A size reduction unit, for milling the ribbons into granules of the desired particle size.

What is rolling compaction?

Compaction in a roll press is a continuous process. Friction between the material and roll surface brings the powder towards the narrow space between the rolls (gap), where the powder is exposed to high stresses leading to the formation of a compact.

What is roller compactor used for?

A road roller (sometimes called a roller-compactor, or just roller) is a compactor-type engineering vehicle used to compact soil, gravel, concrete, or asphalt in the construction of roads and foundations. Similar rollers are used also at landfills or in agriculture.

What is Roller Compactor in pharma?

A roller compactor is pharmaceutical machinery used for tablet manufacturing, as well as powdered fillings for sachets and capsules. The purpose of these machines is to agglomerate the powders containing active ingredients and excipients to form uniformly sized granules.

What is roller compaction in dry granulation?

The roller compaction and dry granulation process takes that fine powder and turns it into a useable substance. Roller Compaction. Roller compactors take the powder and densify it, turning it into a more condensed material. They do this through the use of a feed screw and a pair of compactor rollers.

Why granulation is done?

Why is Granulation Necessary? The granulation process allows particles to stick together more firmly. It increases the particle size of the constituents used, which are mostly very fine powders. The greater the particle size of a constituent, greater will be its compressive or binding ability.

What is the principle of granulation?

Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation.

How do road rollers work?

Road rollers use the weight of the vehicle to compress the surface being rolled or use mechanical advantage (vibrating). Initial compaction of the substrate on a road project is done using a padfoot drum roller, which achieves higher compaction density due to the pads having less surface area.

What is a paver roller?

But also on the building therefore.

What is SLUG in granulation?

Introduction. Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.

What is compaction in pharmaceutical?

Compaction is one method of producing granulates that uses pressure to minimize the space between individual particles. Both processes are essential to the production of pharmaceutical products such as pills, capsules, and tablets.

What is Dry compaction?

The dry compaction of sand and gravel is of particular significance in regions of arid and hot climatic conditions where water is expensive to supply. Laboratory apparatus described developed by Dynapac for compaction by vibration, consists of a 150 mm diameter test cylinder with a vibrating tamper.

What is wet and dry granulation?

Dry granulation and wet granulation are two of them. The main difference between dry granulation and wet granulation is that dry granulation is the process of forming granules without using any liquid solution whereas wet granulation is the process of forming granules by adding a granulating liquid.

What are granules used for?

Granules contain one or more active substances with or without excipients and, if necessary, suitable colouring and flavouring substances. They are mainly used for low-toxicity, high-dose drugs.

Which granulation method is best?

Among these two techniques, wet granulation is the most widespread granulation technique used despite the fact that it involves multiple unit processes such as wet massing, drying and screening, which are complex, time consuming, and expensive requiring large space and multiple equipment.

What are the types of granulation?

Unless the powdered sugar is granulated, it could not efficiently be made into a tablet that has good tablet characteristics such as uniform content or consistent hardness. Two types of granulation technologies are employed: wet granulation and dry granulation.

What are granulating agents?

A granulating agent provided proper moisture to convert fine powder into damp mass ,which after passing through a sieve of suitable number forms granules. The various granulating agents used are water,alcohol,mucilage of starch,mucilage of acacia ,mucilage of tragacanth,gelatin solution,iso-propyl alcohol,acetone etc.

Why powders are converted into granules?

Granulation is carried out for several reasons. It helps prevent the separation or segregation of the primary ingredients in the powder mixture as well as improves the flow of the properties of the mixture. Segregation is due to differences in the size or density of the different components in the mixture.

What do you mean by granules?

Definition of granule



1 : a small particle especially : one of numerous particles forming a larger unit. 2 : any of the small short-lived brilliant spots on the sun’s photosphere.

What’s the difference between powder and granules?

As nouns the difference between powder and granule



is that powder is the fine particles to which any dry substance is reduced by pounding, grinding, or triturating, or into which it falls by decay; dust while granule is a tiny grain, a small particle.

Why are granules brighter?

The rising part of the granules is located in the center where the plasma is hotter. The outer edge of the granules is darker due to the cooler descending plasma. (The terms darker and cooler are strictly by comparison to the brighter, hotter plasma.

What do granules contain?

Primary granules contain cationic proteins and defensins that are used to kill bacteria, proteolytic enzymes and cathepsin G to break down (bacterial) proteins, lysozyme to break down bacterial cell walls, and myeloperoxidase (used to generate toxic bacteria-killing substances).

Are granules lysosomes?

Primary or azurophilic granules are lysosomal in nature. They contain proteases, myeloperoxidase, etc. Their membranes express CD63, which is a useful marker for immunofluorescence and flow cytometry. Secondary granules contain lactoferrin, vitamin B₁₂-binding protein, lysozyme, etc.

What happens if neutrophils are high?

Neutrophils are a type of white blood cell. They help you fight infection. If there are too many neutrophils in your bloodstream, you may develop leukocytosis, or a high total white blood cell count. You may have symptoms such as fevers or recurring infections.

What is degranulation of neutrophils?

Normal neutrophil degranulation involves the release of primary and secondary granules mainly into the phagosome, which prevents host tissue damage (Sengeløv et al., 1995).

Why do neutrophils have granules?

Neutrophil granules house critical enzymes for bacterial and fungal killing, and are mobilized to the phagosome immediately after ingestion of an invader (Figure 78-1). This intracellular trafficking requires molecular motors, which move granules around inside the cell.

What is degranulation of histamine?

Degranulation results in the release of inflammatory mediators (e.g., histamine, prostaglandins, leukotrienes, kinins, serotonin, heparin, and serine proteases). Mast cell degranulation can be initiated by IgE complexes, complement components, mechanical trauma, endotoxins, and free radicals.