What causes aromatization of testosterone?
3 min read
Asked by: Justin Collas
Objective: Aromatization is the biochemical process in which aromatase catalyzes the conversion of testosterone into estradiol, the fundamental pathway for the synthesis of estrogens. When enhanced, it can lead to hyperestrogenism, a well-known risk factor for gynecological cancers.
Why does aromatization happen?
Why Does Aromatization Occur? Aromatization occurs when the body is attempting to maintain homeostasis. Homeostasis is a function that keeps the body at normal levels required to stay healthy. Homeostasis keeps the body in the average ranges for temperature, hormones, mass, and many other factors.
What prevents testosterone from turning into estrogen?
The use of an aromatase inhibitors, (Arimidex or Anastrozole) can stop this conversion and breakdown of testosterone. Arimidex has been used in coordination with TRT in many men’s health testosterone clinics to reduce the breakdown of testosterone, reduce estrogen production and as a treatment for gynecomastia.
What is aromatization in hormones?
Aromatization is the process of converting a nonaromatic ring into an aromatic ring and is catalyzed by aromatase, a P450 enzyme. Aromatization converts androgens into estrogens. Estrogens contain an aromatic six-carbon ring.
What increases aromatase?
Aromatase activity is increased by age, obesity, insulin, gonadotropins, and alcohol. It also appears to be enhanced in certain estrogen-dependent local tissue next to breast tissue, endometrial cancer, endometriosis, and uterine fibroids.
What is aromatization reaction?
Aromatization is a chemical reaction in which an aromatic system is formed from a single nonaromatic precursor. Typically aromatization is achieved by dehydrogenation of existing cyclic compounds, illustrated by the conversion of cyclohexane into benzene. Aromatization includes the formation of heterocyclic systems.
Should I take Arimidex on TRT?
Co-administration of Anastrozole (Arimidex)
Notwithstanding the foregoing, some physicians do treat men on TRT with high estradiol levels by co-administering anastrozole (brand name Arimidex) with TRT at 0.25 mg per day or 0.5 mg every other day.
How can I regain testosterone?
Here are 8 evidence-based ways to increase testosterone levels naturally.
- Exercise and Lift Weights. …
- Eat Protein, Fat and Carbs. …
- Minimize Stress and Cortisol Levels. …
- Get Some Sun or Take a Vitamin D Supplement. …
- Take Vitamin and Mineral Supplements. …
- Get Plenty of Restful, High-Quality Sleep.
Does turmeric lower testosterone?
Are there drawbacks to turmeric supplements? Turmeric may lower testosterone and decrease sperm count in men, which may reduce fertility. High doses of turmeric may affect the absorption of iron, meaning patients with iron deficiency should use caution.
What is a natural hormone blocker?
Natural estrogen blockers
Wild nettle root: Nettle root or nettle leaves are often used to make prostate medication. Nettles contain compounds that act as natural estrogen blockers. Taking supplements can regulate production of the hormone. Chrysin: This flavonoid is found in passionflower, honey, and bee propolis.
How can I lower my aromatase?
Steroidal inhibitors such as formestane and exemestane inhibit aromatase activity by mimicking the substrate androstenedione. Nonsteroidal enzyme inhibitors such as anastrozole and letrozole inhibit enzyme activity by binding with the heme iron of the enzyme.
What increases aromatase in males?
Sex steroids by themselves have been shown to modulate aromatase activity. Vottero et al. (30) reported an increase in aromatase expression in the peripheral blood leukocytes of men who were given testosterone.
What is the strongest natural aromatase inhibitor?
Naringenin, naringin and quercetin were found to be the most potent and were thus selected for further assays. The experiments performed had two arms which aimed at investigating estrogen receptor (ER) modulation and aromatase inhibition potential of the three most potent compounds.
Does green tea increase aromatase?
Laboratory-based evidence suggests that green tea catechins may reduce aromatase enzyme activity [23, 24, 27, 28] by modulating expression of CYP19 isoforms [23]. Another study suggests that chronic exposure to tea catechins may be associated with increased expression of this enzyme [29].
