Scientific evidence that higher mTor levels generated by high protein diets and strength training result in lower life span?

Asked by: Bob Jensen

Does protein increase mTOR?

Protein ingestion acutely elevates amino acid levels in blood and atherosclerotic plaques, stimulating macrophage mammalian target of rapamycin (mTOR) signalling.

Does protein inhibit mTOR?

Within the tumor, we determined that ad libitum feeding of a 7% protein diet or intermittent fasting of a 21% protein diet significantly inhibits mTORC1 signaling.

Do high protein diets result in increased health problems over time?

Studies have shown that certain high-protein diets that are particularly high in red meat-based protein are linked to an increased risk of various health issues, including cancer. Eating more red and/or processed meat is associated with colorectal, breast , and prostate cancer.

What would be the effect of a high protein diet on energy performance?

Increasing protein at the expense of CHOs leads to increased contribution of amino acids to energy expenditure with a concomitant decrease in lipogenesis due to decreased supply of dietary glucose [68] and likely has a negative impact on exercise performance and training intensity [69].

Does exercise reduce mTOR?

Richard-Bulteau et al.²²⁾ reported that mTOR expression decreased in damaged skeletal muscle but increased during the initial period of exercise, and that mTOR played an important role in muscle growth.

What increases mTOR?

The main activators of mTOR are a variety of amino acids and the hormone insulin.

How does mTOR increase protein synthesis?

mTORC1 controls protein synthesis by activating S6 kinase 1 (S6K1) and inhibiting 4E-binding protein 1 (4EBP1) (Ma and Blenis, 2009).

What is the role of mTOR in protein synthesis?

mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

What are the effects of mTOR?

As outlined above, mTOR promotes anabolic cellular processes leading to growth. This is further facilitated by the suppression of protein catabolism, most notably autophagy. Autophagy is a basic catabolic process in the cell that degrades damaged organelles or dysfunctional proteins to gain energy or free amino acids.

How protein really affects your weight strength and health?

Protein is the building block of your muscles. Therefore, eating adequate amounts of protein helps you maintain your muscle mass and promotes muscle growth when you do strength training. Numerous studies show that eating plenty of protein can help increase muscle mass and strength ( 8 , 9 ).

Why an athlete should not eat a high-protein diet?

High-protein diets most often are associated with muscle hypertrophy and strength, but now also are advocated for weight loss and recovery from intense exercise or injuries. Prolonged intake of a large amount of protein has been associated with potential dangers, such as bone mineral loss and kidney damage.

What is the role of high-protein diet?

High-protein diets encourage eating more protein and fewer carbohydrates and fat to boost weight loss, improve energy, and enhance athletic performance. 1 Protein is an essential nutrient for health.

Are high protein diets beneficial?

Answer From Katherine Zeratsky, R.D., L.D. For most healthy people, a high-protein diet generally isn’t harmful, particularly when followed for a short time. Such diets may help with weight loss by making you feel fuller.

Why is protein important for muscle growth?

Protein is extremely important in building muscle because the amino acids (the building blocks of protein) help repair and maintain muscle tissue. After a workout, protein helps you recover from workouts because muscles slightly tear during exercise.