Is probenecid the same as colchicine?

Asked by: Tara Duncan

Probenecid belongs to a class of drugs known as uricosurics. It works by speeding up the removal of uric acid by your kidneys. This decreases uric acid in the blood. Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint(s).

What is another name for probenecid?

Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine.

Can you take probenecid and colchicine together?

Probenecid and colchicine combination does not cure gout. This medicine will help prevent gout attacks only as long as you continue to take it. Probenecid and colchicine combination is available only with your doctor’s prescription.

Does probenecid contain colchicine?

Each tablet contains 500 mg of probenecid and 0.5 mg of colchicine. Children 2 years of age and older: Ask your child’s provider to see what dose your child should take. Children under 2 years of age: probenecid/colchicine cannot be used.

Is there an alternative to colchicine?

ColciGel® is a first line agent in the treatment of acute gout flares and an alternative to oral colchicine in those patients who experience either adverse drug effects (ADRs) or who do not achieve suitable symptom relief.

Is probenecid good for gout?

Probenecid is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks.

What is the generic drug for probenecid?

GENERIC NAME: COLCHICINE/PROBENECID – ORAL (COAL-cheh-seen/pro-BEN-uh-sid)

Which is better allopurinol vs probenecid?

Conclusions: In a large cohort study of 38,888 elderly Medicare patients with gout, use of probenecid appears to be associated with a modest decrease in MI, stroke, and admission for heart failure exacerbation compared to allopurinol.

Does probenecid make you pee?

Nausea, loss of appetite, dizziness, vomiting, headache, sore gums, or frequent urination may occur as your body adjusts to the medicine.

Can probenecid cause joint pain?

The most common side effects of Probenecid are liver problems, nausea, gout flares, joint pain, and rash. Contact your prescriber if any of these side effects occur.

Why was colchicine taken off the market?

“Under the guidance of the FDA’s Unapproved Drug Initiative, Colcrys’s manufacturer, which conducted a 1-week trial (n = 185), received 3 years’ market exclusivity for treatment of acute gout, and the unapproved formulations were soon ordered off the market, resulting in a virtual monopoly.”

What is a natural colchicine?

Colchicine is one of the oldest remedies still in use today. It is derived from the bulb-like corms of the Colchicum autumnale plant, also known as autumn crocus. Its history as an herbal remedy for joint pain goes back at least to the 1500 BCE Egyptian manuscript, the Ebers Papyrus (Figure 1).

What is the safest gout medication?

Allopurinol is considered very safe to take for a long period of time. There are unlikely to be any long-term effects. What will happen if I stop taking it? If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects.

What is the first line drug of choice for treating gout?

Allopurinol is strongly recommended as a first-line urate-lowering medication over all others for all patients. Allopurinol or febuxostat is strongly recommended over probenecid as a first-line treatment for patients with moderate-to-severe chronic kidney disease.

Which is better for gout colchicine or allopurinol?

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working. Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.